ABSTRACT
To evaluate the correlation between the radiomics signature of hepatobiliary phase imaging of gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)and Child-Pugh of liver cirrhosis,establish nomogram prediction model,and assess the predictive value of quantitative assessment of liver reserve function of patients with liver cirrhosis. One hundred patients with liver cirrhosis who met the inclusion criteria were divided into 52 patients with Child-Pugh grade A and 48 patients with Child-Pugh grade B+C according to Child-Pugh classification criteria,and were randomly divided into training set and test set at a proportion of 7∶3.The AK software was used to extract the imaging features of the Gd-EOB-DTPA-enhanced MRI hepatobiliary images of the patients in the training set,and the least absolute shrinkage and selection operator feature selection algorithm was used to reduce the dimension of the data,select the features,and construct the radiomics tags.According to the radiomics label Rad-score,a line chart(nomogram)prediction model was established to predict the Child-Pugh B+C level of liver reserve function.The model was applied to the training set and test set respectively,and the diagnostic efficiency was quantitatively evaluated by receiver operating characteristic(ROC)curve. After dimension reduction and screening of 396 texture feature parameters extracted by AK software,7 image feature parameters were obtained.According to the above characteristics,the radiomics tag Rad-score was constructed and the nomogram prediction model was created.The differences of Rad-score scores between Child-Pugh A and Child-Pugh B+C groups in training set and test set were statistically analyzed by Wilcoxon rank sum test(=0.000, =0.001).The diagnostic efficacy of nomogram prediction model for predicting Child-Pugh B+C grade of liver reserve function in the ROC curve of training set and test set was 0.88 and 0.86 respectively. The nomogram prediction model created according to the radiomics tag Rad-score of patients with liver cirrhosis with different liver reserve functions can be used as a more accurate and reliable auxiliary detection tool for liver reserve function.It provides a new means for clinicians to evaluate liver reserve function more accurately.
Subject(s)
Humans , Contrast Media , Gadolinium DTPA , Liver Cirrhosis , Magnetic Resonance ImagingABSTRACT
Objective: To compare the detectability of hepatocellular carcinoma (HCC) based on DWI during gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhanced MR scanning between short tau inversion recover (STIR) and chemical shift selective (CHESS) sequences. Methods: Thirty-seven patients with pathologically confirmed HCC were selected for retrospective analysis. All patients underwent Gd-EOB-DTPA enhanced MR scanning of the upper abdomen. Images of DWIs with STIR and CHESS sequences were acquired at 13-15 minutes after Gd-EOB-DTPA injection. The signal intensity (SI), standard deviation (SD), ADC of liver parenchyma and SI,ADC of HCC on DWI with STIR and CHESS sequences were measured. And the SNR of liver parenchyma and CNR of HCC were calculated. The visual grade of conspicuity of HCC and the clarity of hepatic anatomical structure were scored on both two sequences. Statistical analysis was performed. SNR of liver parenchyma, CNR of HCC, ADC of liver parenchyma and HCC, as well as visual score of HCC conspicuity, clarity of hepatic anatomical structure were compared between DWI with STIR and CHESS sequences. The consistency of observation scores between two physicians were also analyzed. Results: CNR of HCC of STIR sequence was significantly higher than that of CHESS sequence (P=0.034). SNR of liver parenchyma, as well as ADC of liver parenchyma and HCC of STIR sequence were significantly lower than those of CHESS sequence (all P<0.05). The consistency of visual scores of HCC conspicuity and clarity of hepatic anatomical structure between the two physicians were good (both Kappa≥0.75). Visual scores of physician-1 and physician-2 of HCC conspicuity and the clarity of hepatic anatomical structure were significantly different between STIR and CHESS sequences (all P<0.001). Most of the visual scores of HCC conspicuity of STIR sequence were scored as 4, and most of the clarity of hepatic anatomical structure scores were as 1. The visual scores of HCC conspicuity and clarity of hepatic anatomical structure of CHESS sequence were mainly scored as 3. Conclusion: DWI using STIR sequence is helpful to detecting HCC after Gd-EOB-DTPA administration compared with CHESS sequence.
ABSTRACT
This study describes the first case of biliary peritonitis after radiofrequency ablation diagnosed by magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), a hepatocyte-specific MR imaging contrast agent. The image acquired 300 minutes after the administration of Gd-EOB-DTPA was useful to make a definite diagnosis and to identify the pathway of bile leakage. It is important to decide on the acquisition timing with consideration of the predicted location of bile duct injury.